Youngs will win his 115th cap, surpassing Jason Leonard.
Defending Six Nations champions Wales arrive at Twickenham with confidence somewhat restored by victory over Scotland, and will hope to end a ten-year Six Nations losing run at the home of English rugby.
Wayne Pivac’s side beat England 40-24 in Cardiff last year.
Here’s everything you need to know ahead of the match.
When is England vs Wales?
The match will kick-off at 4.45pm GMT on Saturday 26 February at Twickenham Stadium in south-west London.
How can I watch it?
It will be shown live on ITV 1, with coverage starting from 4pm. It will also be available to stream live and for free for registered users online on the ITV Hub.
The fallow week proved a pleasing one for Eddie Jones, with the Australian able to call upon Courtney Lawes for the first time this tournament. Lawes, who would have captained the side in the absence of Owen Farrell, has been going through return to play protocols after suffering a concussion but is now cleared to play, while Manu Tuilagi was also set to play before suffering an injury setback.
Ben Youngs is set to become England’s most capped men’s player if he makes his 115th appearance on Saturday.
Wales have made a sizeable selection decision by releasing Louis Rees-Zammit to club Gloucester. The young wing was such a star of last year’s tournament but has struggled to sizzle this season, and with Josh Adams available again after injury finds himself out of the squad. Alex Cuthbert appears set to retain his place on the other wing.
Taulupe Faletau is back amongst things to further bolster a competitive back-row, and should lend balance and experience alongside the impressive Taine Basham, arguably Wales’ standout player of the tournament so far.
England (possible): Freddie Steward, Max Malins, Henry Slade, Joe Marchant, Jack Nowell, Marcus Smith, Harry Randall; Alex Dombrandt, Tom Curry, Courtney Lawes (captain), Maro Itoje, Charlie Ewels, Kyle Sinckler, Luke Cowan-Dickie, Ellis Genge. Reserves: Jamie George, Joe Marler, Will Stuart, Nick Isiekwe, Sam Simmonds, Ben Youngs, George Ford, Elliot Daly. Wales: Liam Williams, Alex Cuthbert, Owen Watkin, Nick Tompkins, Josh Adams, Dan Biggar (captain), Tomos Williams; Taulupe Faletau, Taine Basham, Ross Moriarty, Adam Beard, Will Rowlands, Tomas Francis, Ryan Elias, Wyn Jones. Reserves: Dewi Lake, Gareth Thomas, Leon Brown, Seb Davies, Jac Morgan, Kieran Hardy, Gareth Anscombe, Jonathan Davies.
England win: 3/16
Wales win: 6/1
It is nearly ten years since England last lost a home game with Manu Tuilagi in the matchday squad, which speaks both to the centre’s ability and also his national side’s reliance on the midfield bastion. Still, he provides a welcome boost for Eddie Jones, and for as much as Wales showed great improvements against Scotland, a returning Twickenham Six Nations crowd will be confident that they will be pleased come Saturday evening. England 27-20 Wales